Haifa shen

Haifa shen. Fu, Haiwei Sun, Yinglei Yi, Haifa Shen, Hangwen Li, Ling Zhao; Affiliations Jiawu Wan State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, People’s Republic of China Jianmei Yang The persistence and clinical consequences of rabies virus (RABV) infection have prompted global efforts to develop a safe and effective vaccines against rabies. Copeland. Erm, 1 Xuewu Liu, 1 Chun Li, 2 and Mauro Ferrari 1, 4 Haifa Shen 1 The Methodist Hospital Research Institute, Department of Nanomedicine, 6670 Bertner Ave. Apr 24, 2023 · We searched the NCBI database using the keywords “COVID-19”, “SARS-CoV-2” and “mRNA vaccine” for clinical studies reporting the safety and immunogenicity of SARS-CoV-2 vaccine based on delivery system. Bansal, 1 Donato Cosco, 5 Massimo Fresta, 5 Haifa Shen, 1, 2 and Mauro Ferrari 1, 3, * Dickson K Kirui 1 Department of NanoMedicine, Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, Texas, 77030, USA Haifa Shen is the author of this article in the Journal of Visualized Experiments: "Porous Silicon Microparticles for Delivery of siRNA Therapeutics" Apr 20, 2017 · Jianliang Shen 1 , Haoran Liu, Chaofeng Mu, Joy Wolfram, Wei Zhang, Han-Cheon Kim, Guixian Zhu, Zhongbo Hu, Liang-Nian Ji, Xuewu Liu, Mauro Ferrari, Zong-Wan Mao, Haifa Shen Affiliation 1 MOE Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. Therap. 2 tandem-fused heterodimer mRNA vaccine delivered by lipopolyplex, May 2, 2023 · By contrast, sequence H, which has the highest MFE, degraded the fastest with T1/2 of 3. Previous studies have indicated that the multistage vector system serves as a safe and effective vehicle for drug delivery [ 28 - 40 ]. Enhancing chemotherapy response with sustained EphA2 silencing using multistage vector delivery. Since in vitro transcribed mRNA molecules Feb 21, 2017 · Haifa Shen; Lipid-formulated RNA vaccines have been widely used for disease prevention and treatment, yet their mechanism of action and individual components contributing to such actions remain to Jul 21, 2020 · Multiple nanotechnology-based delivery platforms have been developed for mRNA delivery, such as polymer-based polyplex, lipid-based lipoplex, and lipid-coated polymer-based lipopolyplex. Publication date: February 8, 2024. M-Y Shen and X-H Qiu contributed to develop and manufacture SW-BIC-213. He is currently Professor of Nanomedicine in Houston Methodist Academic Institute and Leader of the Innovative Therapeutics Sep 12, 2023 · Background The mRNA vaccine against SARS-CoV-2 has demonstrated remarkable efficacy in protecting against coronavirus disease 2019 (COVID-19), including providing high protection against severe disease during the emergence of variant waves. Filed: December 3, 2021. In this review, an overview of the nanoplatforms for mRNA delivery is provided. 1/2021) Self-assembled nanomedicines offer a versatile approach for developing effective cancer treatments. and Jean Raymond Centennial Chair, Houston Methodist. 2018 Feb 28;272:72-82. Collectively, this core-shell structure offers a promising platform for mRNA 沈海法 Haifa Shen, Ph. 3 h in 10 and 20 mM Mg 2+ buffers, respectively. AU - Ferrari, Mauro. This goal is challenging due to multiple transport obstacles in the Haifa Shen's 4 research works with 634 citations and 578 reads, including: Common Sites of Retroviral Integration in Mouse Hematopoietic Tumors Identified by High-Throughput, Single Nucleotide Nizzero, S. With the rapid approval and broad application of the two prophylactic mRNA vaccines for SARS-CoV-2, there is a great enthusiasm in developing mRNA-based agents for prevention and treatment of human diseases [[4], [5], [6]]. Houston Methodist Research Institute. 004 Aug 10, 2014 · Effective treatment of cancer metastasis to the bone relies on bone marrow drug accumulation. Mice bearing lung metastatic B16-OVA tumors expressing the ovalbumin antigen were treated with the lipopolyplex mRNA, and over 90% reduction of tumor nodules was observed. Conventional nanoparticle platforms, such as liposomes and polymer nanoparticles, typically possess a spherical geometry, generally 10–100 nm in diameter, and are designed specifically for intravenous delivery. , 2015. 1038/nbt. Here we report the first large-scale use of retroviral tagging for cancer gene discovery in the post-genome era. [PMC free article] [Google Scholar] M Mayxay is the principal investigator of this trial. ACS Nano. In this study, we aimed to investigate the safety and immunogenicity of a 2-dose regimen of the LPP-based mRNA vaccine, SW-BIC-213, in Laos. This natural compound has multiple properties that effectively reduce cancer growth. D D, C P, B Yu, Y-Z Wang and R Yan participated in designing the trial and study protocol. Here, we show that molecular targeting of the FATP4 transporter is an effective approach to specifically transport long-chain fatty acid (LCFA)–conjugated peptides across the enterocytic membrane Jul 1, 2016 · Atherosclerosis is a chronic inflammatory vascular wall disease, and endothelial cell dysfunction plays an important role in its development and progression. Y Fang and F-F Zhao contributed to the manuscript writing. The efficacy of cancer immunotherapy is critically dependent on specific physiological and physical processes – collectively referred to as transport barriers – including the activation of T cells by antigen presenting cells, T cells migration to and penetration into the AU - Shen, Haifa. [PMC free article] [Google Scholar] Here we examine the effect of hesperetin on the transforming growth factor-β (TGF-β) pathway. X-L Guo, Y-Z Gui and R-J Pei contributed to laboratory testing. com # These authors contributed equally. mRNA‐based therapeutics are a unique class of drugs for treatment of human diseases. Jul 10, 2023 · Synthetic circular RNA (circRNA) has recently emerged as the next generation RNA technology for vaccine and drug development, featuring its uniqueness in a closed-loop structure and cap-independent translation mechanism. Authors. org. Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY 10065, USA. 沈海法教授于1985年获浙江大学药学院药学学士学位，1997年获休斯顿德克萨斯大学博士学位，2001年在美国国家癌症研究中心完成博士后研究后进入Lexicon Pharmaceuticals公司担任药物研发科学家，2010年回到德克萨斯大学休斯顿医学院担任助理教授。目前，沈海法教授是美国康奈尔 Feb 1, 2024 · 1. haifa. Agarose gel electrophoresis was applied to examine mRNA binding capacity to the cationic PbAE Low oral bioavailability of peptide drugs has limited their application to parenteral administration, which suffers from poor patient compliance. TLDR. Biography. Using high throughput inverse PCR, we cloned and analyzed the sequences of 884 RISs from a Jan 15, 2015 · Jianliang Shen 1 , Xiaoyan Wu 2 , Yeonju Lee 3 , Joy Wolfram 4 , Zhizhou Yang 3 , Zong-Wan Mao 5 , Mauro Ferrari 6 , Haifa Shen 7 Affiliations 1 Department of Nanomedicine, Houston Methodist Research Institute; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University. Professor Cardiothoracic Weill Cornell Medical College United States of America. com View further author information Hangwen Li e Stemirna Therapeutics, Shanghai, People’s Republic of China Correspondence lihangwen@stemirna. 4 ), cytokines that play an important role in mediating anti-tumor immunity through promoting DC maturation. D. Science advances. 1993 - 1997. Introduction. 2013. There are 2 professionals named "Haifa Shen", who use LinkedIn to exchange information, ideas, and opportunities. High Capacity Nanoporous Silicon Carrier for Systemic Delivery of Gene Silencing Therapeutics. Open in a separate window. Charney School of Marine Nov 22, 2023 · Haifa Shen e Stemirna Therapeutics, Shanghai, People’s Republic of China Correspondence shf@stemirna. cesmzw Zhenhua Hu's 4 research works with 309 citations and 1,647 reads, including: Sequential deconstruction of composite drug transport in metastatic breast cancer Nanomedicine involves the use of nanoparticles for therapeutic and diagnostic purposes. These results support the idea that low-MFE designs are more resistant to in-solution degradation, a favourable trait for biological applications. Site-specific delivery of therapeutics will remain a distant reality unless nanocarrier design takes into account the majority, if not all, of the biological barriers that a particle encounters upon intravenous administration. Nature Genetics. Jul 21, 2020 · Chaoyang Meng, Zhe Chen, Gang Li, Thomas W elte, and Haifa Shen* mRNA-based therapeutics are a unique class of drugs for treatment of human. Namely, a first-stage carrier (microparticle) was used to transport second-stage carriers (nanoparticles) to tumor tissue. mRNA vaccines have played a key role in controlling the coronavirus disease 2019 (COVID-19) global pandemic [[1], [2], [3]]. 2011. He is Jun 26, 2020 · Sara Nizzero 1 2 , Shreya Goel 1 , Louis E Hinkle 1 , Xiaoyan Wu 1 3 , Chao Li 1 4 , Mauro Ferrari 1 5 , Haifa Shen 6 7 Affiliations 1 Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA. , Houston, Texas 77030 Jan 1, 2018 · Shen J, Liu H, Mu C, Wolfram J, Zhang W, Kim H-C. hzau. 沈海法教授于1985年获浙江大学药学院药学学士学位，1997年获休斯顿德克萨斯大学博士学位，2001年在美国国家癌症研究中心完成博士后研究后进入Lexicon Pharmaceuticals公司担任药物研发科学家，2010年回到德克萨斯大学休斯顿医学院担任助理教授。目前，沈海法教授是美国康奈尔 A reimagining of conventional nanoparticles is needed to successfully negotiate these impediments to drug delivery. BIOGRAPHY Haifa Shen. Retraction endorsed by Heather Montgomery, Managing Editor, Nanoscale Feb 15, 2014 · Shen J, Xu R, Mai J, Kim HC, Guo X, Qin G. jconrel. 2017; 9 :5329–41. 5973. In article number 2000159, Horacio Cabral and co-workers review the recent progress of self-assembled nanomedicines in clinical studies. com Aug 18, 2023 · Min Zhou, ab Jun Zhao, a Mei Tian, b Shaoli Song, c Rui Zhang, a Sanjay Gupta, d Dongfeng Tan, e Haifa Shen, f Mauro Ferrari f and Chun Li* a Author affiliations * Corresponding authors Hesperetin (4’-methoxy-3’,5,7-trihydroxyflavanone) is a flavanone that can be found in citrus fruit. 48 reports were identified and all of them are lipid nanoparticles (LNP) (22 on BNT162b2, 8 on mRNA-1273, 11 on both BNT162b2 and mRNA-1273, 3 on BNT162b1, 1 on mRNA-1273. May 1, 2017 · Furthermore, the LPP/mRNA vaccine is more potent than the naked mRNA core vaccines in stimulating expression of IFN-β and IL-12 ( Fig. N. Haifa Shen's 175 research works with 11,304 citations and 22,711 reads, including: An inoculation site-retained mRNA vaccine induces robust immune responses against SARS-CoV-2 variants Haifa Shen, MD, PhD Professor Nanomedicine Overcoming Transport Barriers in Cancer Treatment Houston Methodist Research Institute. 1016/j. The retroviral integration sites (RISs) in these tumors thus provide powerful genetic tags for the discovery of genes involved in cancer. Ramirez, 1 Shuqing Chen, 3 and Haifa Shen 1, 4, 5 Qi Shen 1 Department of Nanomedicine, Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030 USA Sep 9, 2023 · Haifa Shen and Mauro Ferrari were contacted about this retraction but did not respond to any correspondence. 1a). Multiple nanotechnology-based delivery platforms have been developed for mRNA delivery, such as polymer-based polyplex, lipid-based lipoplex, and lipid-coated polymer-based lipopolyplex. View author publications. Journal of Controlled Release. 01. 211, 1 on Apr 1, 2020 · Zhenhua Hu 1 , Sara Nizzero 1 2 , Shreya Goel 1 , Louis E Hinkle 1 , Xiaoyan Wu 1 3 , Chao Li 1 4 , Mauro Ferrari 1 5 , Haifa Shen 1 6 Affiliations 1 Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA. Stimulation of interferon- β expression is exclusively dependent on STING, and antitumor activity from the mRNA vaccine is significantly compromised in mice with a defective Sting Location: Haifa · 500+ connections on LinkedIn. Inventors: Haifa SHEN, Dongfang YU, Yongbin LIU. The liver is a major barrier for site-specific delivery of systemically injected nanoparticles, as up to 90% of the dose is usually captured by this organ. Apr 1, 2024 · Here, based on a similar dimeric RBD design as our previous ZF2001 vaccine, we developed a novel broad-spectrum COVID-19 mRNA vaccine, SWIM516, with chimeric Delta-BA. BIOGRAPHY View FREE Public Profile & Reputation for Haifa Shen in Bellaire, TX - Court Records | Photos | Address, Emails & Phone | Reviews | $90 - $99,999 Net Worth Dec 8, 2020 · Ovarian cancer (OC) is the most fatal gynecological malignancy worldwide. degree in 1985 from Zhejiang University Medical School in Hangzhou, China, and his Ph. 2013; 7:9867–80. Biology, Medicine. ]. AU - Shen, Haifa. E Blanco, H Shen, M Ferrari. Med. After completing a four-year postdoctoral fellowship at the National Cancer Institute, he worked on drug development at Lexicon Pharmaceuticals. Jun 26, 2020 · Haifa Shen * [email protected] Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA. Here, we show that molecular targeting of the FATP4 transporter is an effective approach to specifically transport long-chain fatty acid (LCFA)–conjugated peptides across the enterocytic membrane Feb 8, 2018 · Haifa Shen earned his M. edu. Distinguished Endowed Chair in the Department of Nanomedicine at the Houston Methodist Research Institute. Fu, Haifa Shen and View the profiles of professionals named "Haifa Shen" on LinkedIn. During the past two decades, a growing number of nanomedicines have received regulatory approval and many more show promise for future clinical translation. 1126/sciadv. Type: Application. 2018. Chair, Department of Nanomedicine. [This retracts the article DOI: 10. Expand. Yu-Zhou Gui 1 , Xue-Ning Li 2 , Jing-Xin Li 3 , Ming-Yun Shen 4 , Mei-Wei Zhang 1 , Ye Cao 1 , Hong-Rong Xu 2 , Hui Li 2 , Jie Cheng 2 , Liang Pan 1 , Ying-Lei Yi 4 , Li-Yu Liang 1 , Cheng-Yin Yu 1 , Gang-Yi Liu 1 , Chen Yu 1 , Bi-Jie Hu 2 , Feng-Cai Zhu 3 , Fei Liang 2 , Haifa Shen 4 , Jing-Ying Jia 1 , Hang-Wen Li 4 , Jian Zhou 2 , Jia Fan 5 CONTACT Ling Zhao zling604@outlook. Zhu M, Ding X, Zhao R, Liu X, Shen H, Cai C et al. View Haifa Shen’s profile on LinkedIn, a professional community of 1 billion Takeshi Suzuki Haifa Shen. Clin Cancer Res. He spent 8 years in the biopharmaceutic industry after post-doctoral training at the National Cancer Institute, and came back to academia in 2010. 沈海法 Haifa Shen, Ph. Department of Defense grant W81XWH-17-1-0389; National Science Foundation grants DMS-1716737 and DMS-1930583; and the Ernest Cockrell May 1, 2017 · Lipopolyplex-based mRNA vaccine is optimal for dendritic cell uptake and protein expression. Email: agrattoni@houstonmethodist. Methods For Mar 14, 2016 · Haifa Shen. Furthermore, the LPP/mRNA vaccine is more potent than the naked mRNA core vaccines in stimulating expression of IFN-β and IL-12 ( Figure 4 ), cytokines that play an important role in mediating anti-tumor immunity through promoting DC maturation. com, lingzhao@mail. mRNA vaccines represent a promising option against emerging and re-emerging infectious diseases, gaining particular interest since the outb … Nanoparticle fluid dynamics in blood vessels is highly dependent on the size and geometry of the construct. Houston Methodist Research Institute, 6670 Bertner Avenue Sep 24, 2018 · Qi Shen, 1 Jun Li, 1, 2 Junhua Mai, 1 Zhe Zhang, 1 Andrew Fisher, 1 Xiaoyan Wu, 1 Zhaoqi Li, 1, 2 Maricela R. aba0145. Rong Xu. Co-delivery of tumor antigen and dual toll-like receptor ligands into dendritic cell by silicon microparticle enables efficient immunotherapy against melanoma. , Shen, H. Experience: Houston Methodist · Location: Houston · 12 connections on LinkedIn. , & Corradetti, B. F. cn; Haifa Shen shf@stemirna. Nature biotechnology 33 (9), 941-951. In this context, it is important to evaluate the safety of nanoparticles in order to achieve . 3330 Corpus ID: 31793494; Principles of nanoparticle design for overcoming biological barriers to drug delivery @article{Blanco2015PrinciplesON, title={Principles of nanoparticle design for overcoming biological barriers to drug delivery}, author={Elvin Blanco and Haifa Shen and Mauro Ferrari}, journal={Nature Biotechnology}, year={2015}, volume={33}, pages={941-951}, url Feb 15, 2014 · Jianliang Shen 1 , Han-Cheon Kim 2 , Hua Su 3 , Feng Wang 4 , Joy Wolfram 5 , Dickson Kirui 2 , Junhua Mai 2 , Chaofeng Mu 2 , Liang-Nian Ji 3 , Zong-Wan Mao 3 , Haifa Shen 6 Affiliations 1 1. Signed: Min Zhou, Jun Zhao, Mei Tian, Shaoli Song, Rui Zhang, Sanjay Gupta, Dongfeng Tan, Chun Li. Moreover, LPP/mRNA is very potent in mediating tumor cell killing. April 1; 19 ( 7): 1806– 15. However, rational design and optimization of circRNA to improve its stability and protein coding potential remains challenging due to lack of structure prediction tool and Jul 6, 2022 · Haifa Shen, Qihui Wang, Hangwen Li, George Fu Gao, Broad-spectrum Delta-BA. S. Dendritic cells treated with the mRNA vaccine displayed enhanced antigen presentation capability. com; Hangwen Li lihangwen@stemirna. Mechanistically, both the mRNA core and lipid shell are needed to fully stimulate the expression of type I interferons and inflammatory cytokines in dendritic cells. You can also search for this author in PubMed Google Scholar Cancer immunotherapy has become arguably the most promising advancement in cancer research and therapy in recent years. org). We have developed a thioaptamer that specifically binds to E-selectin that is overexpressed in the vasculature of tumor and inflammatory Shen H, Rodriguez-Aguayo C, Xu R, . In this review, we explore and summarize the role of functional inorganic-organic hybrid systems involved in the siRNA therapeutic Nov 22, 2023 · Author contributions: Jiawu Wan and Zongmei Wang planned and performed experiments, analysed data, and wrote the manuscript; Chengguang Zhang performed experiments and analysed data; Jianmei Yang, Yinglei Yi, Haiwei Sun, Yuntao Wu and Ruizhong Shen contributed samples and discussed data; Ming Zhou, Huanchun Chen, Zhen F. Immunobiology & Transplant Science Center. Full Member, Research Institute. Zhenhua Hu, Sara Nizzero, Shreya Goel, Louis E. Over 22,000 American women are diagnosed with OC each year and approximately 14,000 die of this disease, rendering it the Jan 20, 2021 · Self-Assembled Nanomedicines: Clinical Translation of Self-Assembled Cancer Nanomedicines (Adv. We searched the NCBI database using the keywords “COVID-19”, “SARS-CoV-2” and “mRNA vaccine” for clinical studies reporting the safety and immunogenicity of SARS-CoV-2 vaccine based on delivery system. 𝞐. View Shai Shen-Orr’s profile on LinkedIn, a professional community of 1 billion members. This leads to the phosphorylation of a subset of downstream signaling molecules, the receptoractivated Smads, which Dickson K Kirui, 1 Christian Celia, 1, 4 Roberto Molinaro, 1, 5 Shyam S. Date: 25/7/2023. degree at University of Texas/ M D Anderson Cancer Center. A number of applications in biotechnology including cell reprogramming and gene Mar 21, 2018 · Nanomaterial-formulated siRNA systems have potential applications in protection of siRNA from degradation, improving the accumulation in the target tissues, enhancing the siRNA therapy and reducing the side effects. Adhesion molecules such as E-selectin AU - Shen, Haifa AU - Ferrari, Mauro N1 - Funding Information: This work was partially supported by NIH grants U54CA210181, R01CA193880, R01CA222959, U01CA196403, U01CA213759, R01CA226537, and R01CA222007; U. Unlike the popular lipid nanoparticle (LNP), this LPP-delivered mRNA expresses only in the injection site, which avoids potential Jul 9, 2023 · 116 Results 117 118 circDesign approach for circular RNA design 119 120 To implement circDesign for circRNA-based rabies vaccine design, the ORF 121 region encoding RABV-G16, 17 was designed such as to achieve efficient and Ruizhong Shen, Chengguang Zhang, Yuntao Wu, Ming Zhou, Huanchun Chen, Zhen F. Created Date: 3/23/2021 2:35:56 PM 6/2012 – 4/2014 Research Fellow, Houston Methodist Research Institute (PI: Prof. 48 reports were identified and all of them are lipid nanoparticles (LNP) (22 on BNT162b2, 8 on mRNA-1273, 11 on both BNT162b2 and mRNA-1273, 3 on BNT162b1 Frank J. Apr 1, 2013 · Haifa Shen, 1, 2, * Cristian Rodriguez-Aguayo, 3, 4, * Rong Xu, 1 Vianey Gonzalez-Villasana, 3 Junhua Mai, 1 Yi Huang, 1 Guodong Zhang, 1 Xiaojing Guo, 1 Litao Bai The field of immunotherapeutic transport oncophysics investigates the physical processes that drive cancer immunotherapies. For instance, hesperetin has been found to induce apoptosis in cancer cells [ 1 ], prevent angiogenesis [ 2 ], suppress cell migration through inhibition of Oct 10, 2017 · Abstract. Department of Radiation Oncology. 2 RBD dimer delivered by lipopolyplex (LPP). Apr 1, 2020 · Low oral bioavailability of peptide drugs has limited their application to parenteral administration, which suffers from poor patient compliance. Professor of Nanomedicine, Academic Institute. A number of applications in biotechnology including cell reprogramming and gene Sep 1, 2015 · DOI: 10. 9 and 3. (Accepted/In press). These resident macrophages form part of the mononuclear Department of Nanomedicine. Agarose gel electrophoresis was applied to examine mRNA binding capacity to the cationic PbAE Department of Nanomedicine. from the University of Texas at Houston in 1997. This review discusses three main aspects that determine the outcome of an immunotherapy-based treatment from a physical point of view; (i) space, the distribution of cancer and immune cells within tumor masses, (ii) time Sep 29, 2023 · Although mRNA vaccines are known as potent activators of antigen-specific immune responses against infectious diseases, limited understanding of how they drive the functional commitment of CD8+ T An overview of the nanoplatforms for mRNA delivery is provided and their clinical translational potential for protein replacement therapy and for infectious disease and cancer treatment is introduced. Multi-step encapsulation of chemotherapy and gene silencing agents in functionalized mesoporous silica nanoparticles. Haifa Shen received his B. Dec 3, 2021 · Abstract: The present disclosure describes compositions for the treatment of oncological disorder, more particularly to amino acid polymer conjugates with platinum agents for the treatment of cancers. Nov 11, 2021 · Further information and requests for resources and reagents should be directed to and will be fulfilled by the lead contact, Haifa Shen (Hshen@houstonmethodist. 1 September 2002. Molecular targeting of FATP4 transporter for oral delivery of therapeutic peptide. N1 - Funding Information: This work was partially supported with a sponsored research grant from Stemirna Therapeutics , China, and from internal funding sources in Houston Methodist Research Institute , USA. diseases. N1 - Funding Information: M. is grateful for the Ernest Cockrell Jr. Jun 1, 2020 · This research presents a novel probabilistic approach to estimating the response of the immune system to laser-spot assisted, 3D image analysis of central nervous system injury. Daniel Sher Department: Marine BiologyResearch Areas: Chemical Ecology and Microbial OceanographyLaboratory: The Marine Chemical Ecology Lab, Room 291, Multipurpose BuildingPhone: +972-4-8249349 Office: 270/2, Multipurpose BuildingEmail: dsher@univ. +5 authors. from Zhejiang University Medical School of Hangzhou, China in 1985, then received his Ph. Since in vitro transcribed mRNA molecules have relatively low stability and their surface charge prevents Jul 21, 2020 · Multiple nanotechnology‐based delivery platforms have been developed for mRNA delivery, such as polymer‐based polyplex, lipid‐based lipoplex, and lipid‐coated polymer‐based lipopolyplex. by Zhenhua Hu, Sara Nizzero, Shreya Goel, Louis E Hinkle, Xiaoyan Wu, Chao Li, Mauro Ferrari, Haifa Shen. Department of Surgery. Haifa Shen) Research Interests and Backgrounds I am a biologist and material scientist with a strong interest in applying micro/nano-technology platforms for cancer and other diseases drug discovery. Shen earned his M. Kupffer cells are thought to be the main cellular component responsible for nanoparticle accumulation in the liver. Jun 15, 2018 · Shen, Haifa / Methodist Hospital Research Institute: NIH 2020 R01 CA: Mechanism of Intratumoral Transport of Particulate Drugs Shen, Haifa / Methodist Hospital Research Institute: NIH 2018 R01 CA: Mechanism of Intratumoral Transport of Particulate Drugs Shen, Haifa / Methodist Hospital Research Institute Apr 24, 2023 · Evidence before this study. Nanoscale. Read more related scholarly scientific articles and abstracts. 2015. TGF-β signaling is initiated by the binding of a ligand to TGF-β receptors, which thereby form a heteromeric signaling complex. degree in 1997 from the Graduate School of Biomedical Sciences at the University of Texas at Houston and MD Anderson Cancer Center in Houston, Texas. XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway. May 1, 2017 · Lipopolyplex-based mRNA vaccine is optimal for dendritic cell uptake and protein expression. We designed a novel platform for mRNA-based vaccine that consisted of a PbAE/mRNA polyplex core structure packaged into a lipid bilayer envelope (Fig. Immunotherapeutic Transport Oncophysics: space, time, and immune activation against cancer Haifa Shen received his B. The power of retroviral tagging for cancer gene discovery in the post-genome era is demonstrated and a largely unrecognized complexity in mouse and presumably human cancer is indicated. Dr. Hinkle, Xiaoyan Wu, Chao Li, Mauro Ferrari, Haifa Shen Nov 7, 2019 · To address the aforementioned problems, a multistage system was utilized for drug delivery. et al. D. Materials availability CRISPR KO lines of K562 cells that were generated in this study (SDC-1 KO and EXT-1 KO) and parental K562 expressing GFP-CAS9 will be available upon Jan 11, 2022 · Xiaoling Liu, # 1 , 2 , * Junhua Mai, # 1 , * Chaoyang Meng, 1 Aldona J Spiegel, 3 Wei Wei, 2 and Haifa Shen 1 Xiaoling Liu 1 Department of Nanomedicine, Houston Methodist Academic Institute, Houston, TX, 77030, USA in 4 the 5 Jan 1, 2012 · Haifa Shen, 1, 3, 4 Jian You, 2, 3 Guodong Zhang, 1 Arturas Ziemys, 1 Qingpo Li, 1 Litao Bai, 1 Xiaoyong Deng, 1 Donald R. Under the influence of laminar shear stress, however, the endothelium releases homeostatic factors such as nitric oxide and expresses of vasoprotective microRNAs that are resistant to atherosclerosis. Prof. ac. A number of applications in biotechnology including cell The ultimate goal in the field of drug delivery is to exclusively direct therapeutic agents to pathological tissues in order to increase therapeutic efficacy and eliminate side effects. Principles of nanoparticle design for overcoming biological barriers to drug delivery. degree in China and his Ph. doi: 10. , Ferrari, M. The surface proteins in the bone marrow vascular endothelium provide docking sites for targeted drug delivery. il About Research interest Education About Daniel Sher is a Professor of Marine Biology at the Leon H. bv oj fu tu fz uw mu bi mf om